If you’re taking Zoloft for anxiety, you might be wondering when’s the best time to pop that pill. The good news? You’ve got options! You can take Zoloft at any time of day, as long as you stick to the same time every day to maintain consistent levels in your system. Some folks feel drowsy after taking it, while others feel more awake – that’s your cue for timing. Notice how your. Zoloft (Sertraline Hcl) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Zoloft is an antidepressant used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, and post-traumatic stress disorder. Take this medicine only as directed by your doctor, to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine should come with a Medication Guide. Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI). It's used to treat different mental health conditions, including depression and certain types of anxiety disorder, such as panic disorder. Learn about cost, uses, and more of Zoloft (sertraline), a prescription tablet and solution that treats certain mental health conditions in adults and some children. See risks & benefits. Learn more about ZOLOFT® (sertraline HCl), a prescription treatment for depression. Sertraline is an antidepressant medication that works in the brain. It is approved for the treatment of unipolar major depressive disorder (MDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and social anxiety disorder. Sertraline is a medication that increases the amount of serotonin in your brain. Serotonin is a hormone that helps regulate your mood. It treats depression, anxiety, obsessive-compulsive disorder, post-traumatic stress disorder and premenstrual dysphoric disorder. What is this medication?.